(note: shamelessly stolen from xkcd)
This is my favourite comic. I often think of it when I see someone take themselves or life to seriously (or take myself to seriously). Sure there are serious things to deal with in this world, but odds are you are not one of them. Let your hair down and get silly once and a while. Life is too short to take yourself seriously all the time.
Also see this comic for some more life wisdom that highly resonates with me. Note that I linked to it instead of embedding it into my blog to protect my more conservative readers from reading a "bad word". Click if you don't mind the F word once and a while (or just ignore the last line): http://xkcd.com/137/